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In celebration of Women’s Month, the African Centre for Gene Technologies (ACGT) celebrates Dr Botle Precious Damane, Head of Medical Research at Steve Biko Academic Hospital and Senior Lecturer at the University of Pretoria, for her contributions to cancer research,...
Antimicrobial resistance is the ability of disease-causing microorganisms to withstand treatments such as antibiotics. Often described as a silent pandemic, it is already responsible for an estimated 1.27 million deaths each year, with the highest burden in Africa....
Researchers at Rockefeller University are developing new approaches to understand how changes in cancer metabolism alter protein function and influence tumour growth and metastasis. Cancer cells reprogramme their metabolism to support rapid growth and survive...
The human genome contains more than 20,000 genes, but only a fraction are active in any given cell at a time. Researchers from the Krebs Group at the European Molecular Biology Laboratory Heidelberg have developed an experimental approach to examine how cells...
Most people drive through Kruger National Park hoping to spot the Big Five. Few notice the small metallic insects racing across the road beneath their tyres. Yet one of South Africa's greatest ecological engineers is not a lion or an...
The gut microbiome has been linked to gut health, cardiac and metabolic disease, mental health and drug responses. However, its complexity has made it difficult for researchers to examine the full range of interactions among microbial communities. Cancer genomicist...
Researchers at St. Jude Children’s Research Hospital have uncovered how structural changes in the SPOP protein help explain cancer-associated mutations whose effects were previously unclear. SPOP forms part of an E3 ubiquitin ligase complex that controls the levels of...
Macrophages are immune cells that help protect the liver from infection. However, when liver cells accumulate fat, these macrophages can become activated and contribute to metabolic dysfunction-associated steatotic liver disease (MASLD). MASLD ranges from metabolic...
University of Virginia School of Medicine researchers have revealed how errors in the final stage of cell division can affect developing brain cells and may contribute to cancer and neurodevelopmental disorders. The final step of cell division, known as abscission,...
August Weismann’s germ plasm theory of the late 19th century proposed that only germ cells such as sperm and egg cells in animals or pollen and ovule cells in plants transmit genetic information to the next generation, while somatic mutations represent an evolutionary...