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August Weismann’s germ plasm theory of the late 19th century proposed that only germ cells such as sperm and egg cells in animals or pollen and ovule cells in plants transmit genetic information to the next generation, while somatic mutations represent an evolutionary...
Researchers from Wageningen University & Research and the Van Andel Institute have developed a high-precision CRISPR-based methodology that differentiates malignant cells from healthy tissue by exploiting epigenetic "fingerprints." Published in Nature, the study...
Researchers at Oregon State University have developed a novel technique to simultaneously treat lung cancer and its associated muscle-wasting condition, cachexia. Published in the Journal of Controlled Release, the study details the use of lipid nanoparticles (LNPs)...
A large-scale study analysing whole genome sequencing (WGS) data from cancer patients provides new insight into the genetic basis of tumour development and progression. The study, one of the largest of its kind, examined thousands of cancer genomes across multiple...
Whole slide image illustrating the detection of key histological structures such as glands and cells. A recent study from the University of Warwick, published in Nature Biomedical Engineering, evaluates the reliability of artificial intelligence (AI) tools designed to...
Researchers develop a CRISPR tool that directly edits and screens genes in primary acute myeloid leukaemia cells from patients. Scientists from Penn Medicine and Children’s Hospital of Philadelphia have created a CRISPR-based functional genomics platform that can...
Structure and specificity of the colibactin-DNA interstrand cross-link. Colibactin is a potent and highly unstable toxin produced by certain strains of Escherichia coli and other gut bacteria. It is known to cause DNA mutations linked to colorectal cancer, but its...
Enhancing the base mismatch sensitivity and specificity of FnCas9 through protein engineering. Liquid biopsy is becoming increasingly valuable for cancer detection and treatment monitoring, but its effectiveness is limited by the extremely low amounts of tumor-derived...
Scientists at UCL and Great Ormond Street Hospital (GOSH) have developed a world-first gene therapy, BE-CAR7, using base-edited immune cells to fight T-cell acute lymphoblastic leukemia (T-ALL), a rare and aggressive blood cancer. Base editing is an advanced version...
Scientists at the University of South Australia have developed an AI-powered method that reveals how groups of genes work together to drive cancer progression, offering a path toward earlier and more precise treatments. Published in Royal Society Open Science, the...