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The aminoglycoside-modifying enzyme Eis2 activates FF-NH2. Scientists at St. Jude Children's Research Hospital have developed a strategy that turns bacterial drug resistance mechanisms against the pathogen itself. By using a structurally modified form of the...

To accelerate the discovery of new antibiotics, microbiologist Cesar de la Fuente develops computational tools to look for (“encrypted”) antimicrobial peptides hiding in the genomes of a wide range of organisms. Nearly a century after the discovery of penicillin, the...

The MetaGraph framework. The massive global datasets created by Next-Generation Sequencing (NGS), such as the American SRA and European ENA, contain around 100 petabytes of DNA/RNA data, a volume equivalent to all text on the internet. Traditionally, searching this...

Researchers used a new spatial proteomic method to map protein localisation changes during viral infection. Scientists from the Chan Zuckerberg Biohub, along with mass spectrometry platform leader  Josh Elias have introduced an innovative mass spectrometry-based...

Identification of RBP4 as an enhancer of latent HIV. Researchers at Ulm University Hospital  have identified a method to reactivate latent HIV viruses using the body’s own RBP4 protein, a vitamin A transporter. This discovery offers a novel avenue for developing...

Representative morphometric and focal adhesion images of HFF cells following MYH9-intron 3 enhancer repression or MYH9 promoter repression with CRISPRi. Researchers at Duke University have shed light on mysterious “dark” stretches of the genome non-coding DNA whose...

Genome-wide fitness screens in human primary CAR T cells with the CELLFIE platform. Customized genetic engineering has opened a new frontier for enhancing CAR T cells, the "living drugs" used to fight cancer. While this therapy is a milestone in modern medicine, its...

Researchers at MIT have developed novel prime-editing tools with markedly improved precision, potentially reducing unwanted mutations and enhancing safety for therapeutic applications. Prime editing is viewed as an appealing alternative to traditional CRISPR-Cas9...

ASOs silence ΦKZ transcripts in Pseudomonas. Researchers at the Helmholtz Institute for RNA-based Infection Research (HIRI) and the Institute of Molecular Infection Biology (IMIB) have developed a new RNA-based method to investigate bacteriophage biology....