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Researchers used a new spatial proteomic method to map protein localisation changes during viral infection. Scientists from the Chan Zuckerberg Biohub, along with mass spectrometry platform leader Josh Elias have introduced an innovative mass spectrometry-based...
Identification of RBP4 as an enhancer of latent HIV. Researchers at Ulm University Hospital have identified a method to reactivate latent HIV viruses using the body’s own RBP4 protein, a vitamin A transporter. This discovery offers a novel avenue for developing...
Representative morphometric and focal adhesion images of HFF cells following MYH9-intron 3 enhancer repression or MYH9 promoter repression with CRISPRi. Researchers at Duke University have shed light on mysterious “dark” stretches of the genome non-coding DNA whose...
Genome-wide fitness screens in human primary CAR T cells with the CELLFIE platform. Customized genetic engineering has opened a new frontier for enhancing CAR T cells, the "living drugs" used to fight cancer. While this therapy is a milestone in modern medicine, its...
Researchers at MIT have developed novel prime-editing tools with markedly improved precision, potentially reducing unwanted mutations and enhancing safety for therapeutic applications. Prime editing is viewed as an appealing alternative to traditional CRISPR-Cas9...
A week away from the lab, a week for proteomics. This is the essence of the Ubuntu Proteomics Summer School (UPSS). Since its beginning, UPSS has become one of Africa’s most highly anticipated scientific training events. This week-long residential program brings...
ASOs silence ΦKZ transcripts in Pseudomonas. Researchers at the Helmholtz Institute for RNA-based Infection Research (HIRI) and the Institute of Molecular Infection Biology (IMIB) have developed a new RNA-based method to investigate bacteriophage biology....
Scientists at Massachusetts General Brigham have developed a customised gene-editing therapy that could offer hope for children with multisystemic smooth muscle dysfunction syndrome (MSMDS), a rare and often fatal condition. MSMDS is typically caused by a mutation in...
Cryo-EM processing workflow of SLC45A4 in LMNG, including local and global resolution estimates. Scientists have identified a genetic link to chronic pain that may help guide the development of more precise treatments. By analysing large-scale datasets, including the...
Cancer spheroid behaviour in different HMW-HA concentrations. (A) Chemical structure of HA. Researchers at the University of Cambridge have identified a new way to suppress the spread of glioblastoma, the most aggressive form of brain cancer. Instead of targeting the...