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Dysfunction in the movement of RNA polymerase II (Pol II), the enzyme that transcribes DNA into RNA, has been linked to cancer and aging. Previously, technical hurdles prevented scientists from understanding precisely how this molecular machine accelerates, pauses,...
A translation-control strategy based on DNA–mRNA hybrids. The damaged base (in red) is removed by a repair enzyme, after which the DNA and mRNA dissociate, allowing translation factors and ribosomes to bind and initiate protein translation. mRNA, known from COVID-19...
Graphical abstract. Yale researchers David Breslow and Mustafa Khokha have developed a novel CRISPR screening technology that provides unprecedented insights into cilia, tiny hair-like cellular structures whose defects are linked to a range of paediatric...
Researchers from the Turku Bioscience Center at the University of Turku, Finland, including Professor Laura Elo's Computational Biomedicine research group, have developed a new machine learning-based algorithm called Coralysis. This method addresses a major challenge...
Snapshots from all-atom MD simulations tentatively indicate that non-specific interactions of the polyadenine oligos with the SiNx surfaces are responsible for the extended protein linker–oligo translocation dwell times in the ssNPs. A technology developed in the...
Structural comparison of AAC(3)-Ia, AAC(3)-XIa, and AAC(3)-IIIa. The global battle against antibiotic-resistant superbugs has become more challenging following a discovery by researchers at McGill University. They identified two enzymes that use a never-before-seen...
Images draw a comparison between the simulated folding and experimentally determined structures of RNA stem loops. A new study led by Associate Professor Tadashi Ando from the Department of Applied Electronics, Tokyo University of Science marks a major step forward in...
Structural variants detected by GPM. Traditional genetic tests analyse DNA in a one-dimensional way, often missing crucial, disease-causing structural changes. A study in The Journal of Molecular Diagnostics introduces a new method called Genomic Proximity Mapping...
The aminoglycoside-modifying enzyme Eis2 activates FF-NH2. Scientists at St. Jude Children's Research Hospital have developed a strategy that turns bacterial drug resistance mechanisms against the pathogen itself. By using a structurally modified form of the...
To accelerate the discovery of new antibiotics, microbiologist Cesar de la Fuente develops computational tools to look for (“encrypted”) antimicrobial peptides hiding in the genomes of a wide range of organisms. Nearly a century after the discovery of penicillin, the...