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Structural models predict the small molecule-binding site on FOXA1 is proximal to DNA. Hormone-driven cancers, like those of the breast and prostate, often rely on a tricky-to-target protein called Forkhead box protein 1 (FOXA1). FOXA1 mutations can enable these types...
Graphical abstract. In the 1980s, scientists knew little about the X and Y chromosomes. What they did understand was that every cell in the body contains 23 pairs of chromosomes. Each of these pairs is similar, except one. While females typically have two X...
A small RNA molecule can stall cell division by disrupting the abundance of ribosomes. All cells in the body reach a point where they stop dividing, but some get there quicker under the influence of pressures, such as DNA damage or oxidative stress.1 Biologists have...
For thousands of years, humans likely learned about herbal remedies by observing other animals’ behavior. The Navajo people credit brown bears with leading them to the osha root (Ligusticum porteri), which they use to relieve headaches, treat infections, or chase...
Differentiation of human iPSCs to pyramidal cortical neurons via dual SMAD inhibition. Genetic prion disease generally manifests with cognitive difficulties, poor muscle control and abrupt jerking movements of muscle groups and/or entire limbs. The three major...
Medication up-titration regimens. Lamotrigine, a drug commonly used to treat epilepsy and certain mood disorders, has been shown to be an excellent treatment option for a rare genetic neuromuscular disease known as non-dystrophic myotonia, in a world-first trial led...
Cells before and after TRAMs were introduced. TRAMs link a shuttle protein (red), and a target protein (green). Without the TRAM, the target protein resides in the nucleus (left), and upon TRAM treatment, the target protein is pulled into the cytoplasm by the shuttle...
Eric Schreiter and Luke Lavis thought they had figured it out. In 2021, the Janelia group leaders reported that they had developed a way to combine Schreiter's engineered protein biosensors and Lavis's bright, fluorescent Janelia Fluor dyes. These sensors, which could...
Mouse airway stem cells are cultured to identify regulators of multiciliated cell differentiation. The multiciliation cycle generates hundreds of centrioles (cyan) during differentiation, each of which will give rise to a cilium. Cell junctions are labelled in...
Findings from a new study suggest that protein isoforms may be more abundant during neurodevelopment than previously thought. Aprocess as intricate as brain development requires precisely controlled expression of crucial genes, but it’s the different flavors of a...