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sAPPβ and Aβ42 levels are significantly reduced in CSF samples of APP A673T variant carriers as compared to controls. Peptide levels were measured with ELISA from CSF samples. Levels of sAPPα and sAPPβ were normalized to sAPPtot (total levels of soluble APP α+β). Data...
The Director of the US National Cancer Institute’s (NCI) Dr Barry O’Keefe recently visited Pretoria to deliver seminars on Natural Products Drug Discovery and build on collaborations. Dr O’Keefe was co-hosted by the University of Pretoria’s Biodiscovery Centre (in the...
Breast cancer is resistant to immunotherapies; therefore, bioengineers and oncologists seek to develop a slew of therapeutic strategies to overcome this challenge. In a new report in Science Advances, Kerui Wu and colleagues in the departments of cancer biology,...
Comparative visualization of domains within OmpU associated with bile resistant phenotypes. (A). Multiple sequence alignment of ompU alleles resistant and sensitive to whole bile. Conserved residues are indicated by dots and those absent are indicated by gray boxes....
A major challenge in human genetics is understanding which parts of the genome drive specific traits or contribute to disease risk. This challenge is even greater for genetic variants found in the 98% of the genome that does not encode proteins. A new approach...
A world-first trial at UCL and UCLH has found a new genetic therapy for Alzheimer's disease that is able to safely and successfully lower levels of the harmful tau protein known to cause the disease. The trial, led by consultant neurologist Dr. Catherine Mummery (UCL...
Studies have indicated that early and mid-successional plants generally suffered from negative to neutral plant-soil feedback. However, the role of such plant-soil feedback during the postglacial primary succession of plants and microorganisms has not been fully...
Cancer cells (red), cell nuclei (cyan), stroma/desmoplasia (green), active stroma-specific marker (purple). One of the newest types of cancer drugs, immunotherapies called immune checkpoint inhibitors, has transformed the treatment of lung cancer over the last decade...
Single cell sequencing is a collection of methods that researchers use to isolate and analyze sequence information from individual cells. Named the Nature Method of the Year in 2013,1 single cell sequencing techniques allow researchers to understand more than ever...
DNA is made up of adenine-thymine (AT) bonds and guanine-cytosine (GC) bonds. The frequency of each type of bond differs substantially across bacterial species. A new study uses this quirk of bacterial genetics to determine the origin and spread of various genes for...