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A gene variant found almost exclusively in the genomes of people of African ancestry increases the risk of developing Parkinson's disease, according to an international study of nearly 198,000 participants with this genetic background. Published in The Lancet...
Cooking food thoroughly and avoiding some types of vegetables and salad during a course of antibiotic treatment could potentially reduce antibiotic resistance, by preventing bacteria carrying resistance genes getting into the gut, according to a new study. New...
An illustration showing flashing neurons. Epilepsy in infants ranges in severity and can leave caregivers with questions about their child's health. While genetic testing to help determine the cause of epilepsy is possible, comprehensive testing does not always...
Proper regulation of LRRK2 levels is important for Parkinson's disease (PD). ATIC, a purine biosynthesis pathway enzyme, and its substrate precursor AICAr regulate LRRK2 mRNA levels via an mRNA decay pathway. AICAr suppresses LRRK2 expression and can rescue...
Integrated Biosciences has developed novel tools to manipulate the integrated stress response (ISR), a key hallmark of aging. The team is using optogenetics to activate the ISR in a “cellular virtual reality” system and has shown that manipulating the duration and...
Researchers at the Berlin Institute of Medical Systems Biology of the Max Delbrück Center (MDC-BIMSB) have developed a technique called Genome Architecture Mapping ("GAM") to peer into the genome and see it in glorious technicolor. GAM reveals information about the...
EPFL researchers have achieved near-perfect control over the manipulation of individual molecules, allowing them to be identified and characterized with unprecedented precision. Aleksandra Radenovic, head of the Laboratory of Nanoscale Biology in the School of...
Population-level changes in the genetic make-up of one of the world's deadliest animals could provide a key in the fight against malaria, proponents of a radical new technology argue. So-called gene drive technology, where genetic changes are passed down through...
Development of the BRCA-mt signature. UMAP representation of BRCA-mt and BRCA-wt samples from all evaluated cohorts without (a) and after (b) batch adjustment (N = 653). Volcano plots showing differentially expressed miRNAs between BRCA-mutated and wild-type samples...
The proposed method involves using water microdroplets as tiny bacterial cultures and bioreactors and then sorting them based on their fluorescence intensity. The Q-bodies are designed to become fluorescent upon binding to a target protein. Thus, fluorescence...