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Massively parallel characterization and prediction of gene regulatory activity in the developing brain. The study, from scientists at Gladstone Institutes and University of California, San Francisco (UCSF), establishes a comprehensive catalog of genetic sequences...
By combining two innovative approaches, researchers can now sequence the full spectrum of mutational differences between individual cells’ genomes. Traditional sequencing is often likened to making a smoothie: researchers blend a bunch of cells, obtain an average...
While the CRISPR-Cas9 genome editor has the potential to revolutionize the treatment of genetic diseases, targeted delivery strategies, such as to the lungs, have been lacking. CRISPR-carrying lipid nanoparticles enabled researchers to correct a rare nonsense mutation...
As axonal mitochondria are lost, changes in the subunits of eIF2 are seen which hamper translation and autophagy and cause the accumulation of proteins in cells. Researchers from Tokyo Metropolitan University have identified how proteins collect abnormally in neurons,...
Scientists at the Ineos Oxford Institute (IOI) have found a new potential combination therapy to combat antimicrobial resistance (AMR) by targeting two key bacterial enzymes involved in resistance. The study, "The Triple Combination of Meropenem, Avibactam, and a...
TFDP1, a modulator of genome accessibility. In a study recently published in Nature Genetics, researchers from Nano Life Science Institute (WPI-NanoLSI), Kanazawa University explore chromatin accessibility, i.e., endogenous access pathways to the genomic DNA, and its...
A collaborative research team has pioneered a new stem cell model to help personalize treatment for patients suffering from rare forms of immunodeficiency. The research findings were published in the Journal of Allergy and Clinical Immunology. Primary...
Alterations in metabolism of lipids, amino acids, glucose, nucleotides, and pulmonary and gut microbiome play a crucial role in COPD development. These metabolites have great potential as early diagnostic markers and targeted clinical interventions. Chronic...
Researchers edit RNA to bypass genome editing limitations in CAR T cell engineering. Many foundational research technologies have transformed cellular therapies, moving treatments from concept to clinic. In the past decade, chimeric antigen receptors (CAR) and genome...
Pancreatic cancer cells (blue) growing as a sphere encased in membranes (red). An investigational exosome-based liquid biopsy accurately detected 97% of stage 1-2 pancreatic cancers when combined with the biomarker CA 19-9, according to research presented at...