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Identification of TMEFF1 as an HSV-1 RF expressed in neurons. More than half of us are carriers of chronic herpesvirus infections. But even though the herpesvirus can infect our nerve cells, it rarely causes serious infection of the brain. Researchers from Aarhus...
Researchers used optogenetics to control muscles in mice, an approach that may reduce the muscle fatigue associated with conventional stimulation with neuroprosthetic devices. In the last few decades, individuals with mobility issues have seen a flurry of advancements...
An analysis of blood samples from thousands of study participants, led by researchers at UT Southwestern Medical Center, revealed 18 proteins associated with both heart failure and frailty, conditions that commonly develop in late life. Their...
During the development of colitis, the mouse distal colon undergoes remarkable cellular remodeling through healthy, early disease, peak, and recovery stages (left to right). Mapping the intestinal cells during this transformation could help researchers understand...
A super-sensitive touch sensor protein called Piezo1 can be found throughout the body. New research shows it doesn’t work the way we thought. At top, the sensor as it appears unstimulated, at bottom the flattened shape it assumes when triggered by touch. The human...
Researchers found an unexpected link between vitamin D and the gut microbiome in enhancing anti-cancer immunity in mice. Science has many historic examples of accidental discoveries that changed the world. In the modern laboratory, such moments continue to pave the...
Cholera infections caused by Vibrio cholerae bacteria can be life-threatening and the trigger is the cholera toxin produced by the bacteria. It binds to the surface of intestinal cells—more precisely, to certain "sugar lipids" (GM1 gangliosides, GM1) on the cell...
Generative artificial intelligence can design new drugs including antibiotics, but these models often produce chemicals in silico that are difficult to synthesize in the laboratory. Clinicians routinely administer antibiotics before surgeries to reduce the risk of...
Rare bacterial strains have been difficult to capture when sequencing the human microbiome. Human bodies are teeming with trillions of microbial cells that comprise the microbiome, many of them bacteria. Although they may be small, some of these bacteria maintain...
A newly developed method called ReapTEC allowed the discovery of thouands of active bidirectional enhancers. Further anaylis of GWAS data revelaed that various immune-mediated diseases, like multipkle sclerosis and rheumatoisd arthritis, are related to genetic...